When doing spreadsheet work, I like Grist (disclaimer, I work at the company that makes it), because it lets me use python formulas. Once I know how to access cells and tables, I don’t have to remember weird spreadsheet-specific commands - I can just use python list comprehensions.
For example, when I wanted to wish someone a happy birthday every day for a week, it was super easy to import the latest exoplanet data and do some orbital math in python to see which exoplanets are back in about the same point in their orbit as they were when that special someone was born.
It is a simple difference but a real pleasure.
By the way no, I wasn’t born in January 8, 1935, that was someone else.